Who are you, in one plain sentence?
The Vascular Anomalies Center at Children’s Hospital Los Angeles is a nationally recognized multidisciplinary program for diagnosing, treating, and managing vascular malformations and tumors in children — and, per the ISSVA registry, adults — with particular strengths in genetic testing, sirolimus-based systemic therapy, and a recently expanded interventional radiology capability featuring equipment not found at other pediatric hospitals.
Who do you see?
Their published scope is children, with the ISSVA listing noting Children & Adults. Children with urgent concerns are seen promptly — a specific commitment stated on their medical professionals page, along with a nurse practitioner who helps expedite testing and assessments. Worth confirming when you contact them: whether adult care is available for your specific condition, and whether telehealth intake applies to your situation.
What conditions do you treat?
Their published program describes the full range of vascular anomalies — all types of vascular tumors and vascular malformations, including those associated with genetic conditions and those that have historically had a poor prognosis. Genetic testing is specifically highlighted as an in-house capability, including a genetic testing panel developed to make diagnosis more efficient. Sirolimus is listed as an innovative option helping many patients achieve excellent outcomes without surgery. Worth asking: whether in-house genetic testing has been done for your condition, and whether targeted systemic therapy protocols exist for your syndrome.
What does your team look like?
Their published team includes surgeons, interventional radiologists, hematologist-oncologists, and dermatologists, described as collaborating in real-time to tailor therapies to each patient’s needs. A nurse practitioner coordinates tests and treatments and provides monitoring and care coordination — a specific support role that reduces the burden on families navigating multiple appointments. A new interventional radiology suite was recently opened with equipment not found at other pediatric hospitals.
What can you actually do here?
Publicly described capabilities include comprehensive diagnostic assessment (medical history, physical exam, imaging including ultrasound, CT, and MRI, and genetic testing), sclerotherapy via interventional radiology, medical therapies including sirolimus, and surgery when necessary performed by pediatric subspecialists. Inpatient acute and supportive services are available for life-threatening complications, including intubation for severe airway concerns and pain crisis management. Clinical trials give eligible patients access to additional treatment options.
How do I get in?
Phone for medical professionals: 323-361-2154. Dermatology Department appointments: 323-361-4191. ISSVA-listed contact: Erin Delfosse (edelfosse@chla.usc.edu). Address: 4650 Sunset Blvd, Los Angeles, California 90027. Program: chla.org/vascular-anomalies-center. Virtual visits are described as available. Worth confirming: current intake procedures and whether virtual intake applies before scheduling travel.
What makes you different?
For the West Coast — historically underserved relative to Boston and the Midwest for dedicated congenital vascular anomaly care — CHLA represents a significant regional anchor. Their specific investment in in-house genetic testing for vascular anomaly syndromes, combined with access to sirolimus and other systemic targeted therapies, places them within the cohort of programs capable of managing the genomically-driven conditions in the PROS spectrum. The new interventional radiology suite signals continued institutional investment rather than a program resting on historical reputation. We found in our community that West Coast families who needed more than local dermatology care but couldn’t access Boston or Cincinnati often reached CHLA as the most comprehensive regional option.
In Their Own Voice
CHLA describes their Vascular Anomalies Center as home to some of the nation’s foremost pediatric vascular anomalies specialists, with few programs in the country having the depth and breadth of expertise they offer. Their published approach emphasizes same-visit diagnosis and treatment planning — a commitment that most children receive a diagnosis and personalized treatment plan during a single visit. The nurse practitioner model for care coordination is explicitly described as a mechanism to reduce the tracking burden on families.
Genetic testing at CHLA’s VAC is described as both a diagnostic tool and a research focus. Medical geneticist Matthew Deardorff, MD, PhD joined the team in 2020 specifically to advance genetic diagnosis for vascular anomaly syndromes. A genetic testing panel is under development to make diagnosis more efficient. The new interventional radiology suite, described as featuring equipment not found at other pediatric hospitals, reflects a specific capital investment in procedural capabilities.
Source: chla.org/vascular-anomalies-center · chla.org/vascular-anomalies-center/team · chla.org/vascular-anomalies-center/medical-professionals · ISSVA Multidisciplinary Teams Registry (Erin Delfosse, contact). Verified: July 2026.
Pedigree
| Program | Vascular Anomalies Center |
| Address | 4650 Sunset Blvd, Los Angeles, CA 90027 |
| Phone (Medical Professionals) | 323-361-2154 |
| Phone (Dermatology / Appointments) | 323-361-4191 |
| ISSVA Contact | Erin Delfosse — edelfosse@chla.usc.edu |
| Program URL | chla.org/vascular-anomalies-center |
| Patients | Children and Adults (per ISSVA listing) |
| ISSVA Registry | Listed — Multidisciplinary Teams |
| Capabilities | Genetic testing (in-house) · Sirolimus · Sclerotherapy · Surgery · New IR suite · Clinical trials · Inpatient acute/supportive care |
| Notable | New IR suite with equipment not found at other pediatric hospitals · Genetic testing panel development · Matthew Deardorff, MD PhD (Medical Genetics, joined 2020) |
Verification & Catalog Status
Catalog Cross-Reference: Pending — see Care4-Rare Compendium